你可能要把第一和第二选项合在一起。新冠病毒可能是经人工改造后的自然病毒。没有直接证据,但有二个间接理由:1,NIH资助的课题计划中确实包括改造蝙蝠冠状病毒. 2, 石正丽的类似的文章已发表在2015年Nature Medicine。石正丽在这篇文章中所起的作用主要是提供蝙蝠冠状病毒负责识别进入人宿主细胞的S蛋白序列信息. 对S蛋白序列的改造可以提高R0。这种改造(gain of function)可能只是在S1和 S2之间加入一个Furin proteases cleavage site. Data indicated that insertion of a furin cleavage site in the HA of highly pathogenic avian H5N1 influenza viruses leads to replication in multiple tissues and higher pathogenicity.
“The NIH research consisted of two parts. The first part began in 2014 and involved surveillance of bat corona viruses. The program funded Shi Zheng-Li, a virologist at the Wuhan lab, and other researchers to investigate and catalogue bat corona viruses in the wild. This part of the project was completed in 2019. The second part of the project began in 2019. It included additional surveillance work but also gain-of-function research for the purpose of understanding how bat corona viruses could mutate to attack humans. The project was run by EcoHealth Alliance, under the direction of Dr. Peter Daszak, an expert on disease ecology. NIH canceled the project on April 24th, Politico reported. The project proposal states: ‘We will use S protein sequence data, infectious clone technology, in vitro and in vivo infection experiments and analysis of receptor binding to test the hypothesis that % divergence thresholds in S protein sequences predict spillover potential’。”
当然,石正丽在武汉的同行竟争者们也有很大的嫌疑。特别是位於疫情曝发中心的湖北省防疫站和武汉市防疫站(CDC)的病毒研究室。在疫情曝发之前,多数蝙蝠病毒不会传染人, 人们可以在P1实殓室研究蝙蝠病毒。
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