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Resveratrol- nature papers

作者：frigate.book 于 2007-10-10 11:09 发表于最热闹的华人社交网络--贝壳村

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Resveratrol: Red Wine Extract Has Been Linked to Life Extension
By David Barnet

Recent studies suggest that resveratrol, a red wine extract, may be able to extend our life (study - D Sinclair of Harvard Medical School in Boston and colleagues at the University of Connecticut and Brown University in Rhode Island - published in July 13 issue of Nature).

The contolled study showed that fries and worms fed on resveratrol live 30% longer than those that were not fed resveratrol. Because all creatures share many biological processes there seems to be compelling evidence that this red wine compound may also extend life in humans.

Before these studies resveratrol was intrinsically linked to protection against heart diseases mainly because of the high concentration of antioxidative parts of this compound. However, the new findings seem to be unrelated to the antioxidative properties of resveratrol and so life extension must come from a different property of the extract. The most compelling theory is that resveratrol may have a calorie-restriction mechanism that activates proteins called sirtuins similar to sir2. Sir2 is an important protein which is an important regulator of the aging process.

Unlike actual calorie restriction, resveratrol has no negative impact on fertility. Actually, evidence suggests that resveratrol improves fertility.

Currently researchers are trying to duplicate the same results in mice, to show that mammals too benefit from resveratrol.

By consuming resveratrol supplements, we may gain the following protective benefits:

• decreased risk and severity of strokes
• Reduction in severity of Alzheimer’s disease
• Improved skin healing
• Protection against pancreatitis
• Protect against diabetic kidney disease
• Protect against liver damage
• Protect against osteoarthritis
• Suppression of appetite and in turn weight control or loss
• Improved sperm production
• Inhibition of cataract formation
• Inhibit proliferation of the herpes simplex virus

Many people are taking resveratrol supplements now that this strong evidence of life extension with resveratrol exists. The supplement is inexpensive and has minimal potential side effects. To find out more visit our free http://www.ResveratrolHealth.com information and news resource.

Resveratrol improves health and survival of mice on a high-calorie diet

Joseph A. Baur^1,¹³, Kevin J. Pearson^2,¹³, Nathan L. Price², Hamish A. Jamieson⁷, Carles Lerin⁸, Avash Kalra², Vinayakumar V. Prabhu³, Joanne S. Allard², Guillermo Lopez-Lluch⁹, Kaitlyn Lewis², Paul J. Pistell², Suresh Poosala⁴, Kevin G. Becker³, Olivier Boss¹⁰, Dana Gwinn¹¹, Mingyi Wang⁵, Sharan Ramaswamy⁶, Kenneth W. Fishbein⁶, Richard G. Spencer⁶, Edward G. Lakatta⁵, David Le Couteur⁷, Reuben J. Shaw¹¹, Placido Navas⁹, Pere Puigserver⁸, Donald K. Ingram^2,¹², Rafael de Cabo² & David A. Sinclair¹

Department of Pathology, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Laboratory of Experimental Gerontology,
Gene Expression and Genomics Unit,
Research Resources Branch,
Laboratory of Cardiovascular Science, and
Laboratory of Clinical Investigation, Research Resources Branch of the Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA
Centre for Education and Research on Ageing, and the ANZAC Research Institute University of Sydney, Concord, New South Wales 2139, Australia
Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Centro Andaluz de Biologia del Desarrollo, Universidad Pablo de Olavide-CSIC, 41013 Sevilla, Spain
Sirtris Pharmaceuticals, Inc., 790 Memorial Drive, Cambridge, Massachusetts 02139, USA
Molecular and Cell Biology Laboratory, The Salk Institute, 10010 N Torrey Pines Road, La Jolla, California 92037, USA
Nutritional Neuroscience and Aging Laboratory, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
These authors contributed equally to this work.

Correspondence to: Rafael de Cabo²David A. Sinclair¹ Correspondence and requests for materials should be addressed to D.S. (Email: david_sinclair@hms.harvard.edu) or R.deC. (Email: deCaboRa@grc.nia.nih.gov).

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Resveratrol (3,5,4'-trihydroxystilbene) extends the lifespan of diverse species including Saccharomyces cerevisiae, Caenorhabditis elegans and Drosophila melanogaster. In these organisms, lifespan extension is dependent on Sir2, a conserved deacetylase proposed to underlie the beneficial effects of caloric restriction. Here we show that resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice on a standard diet and significantly increases their survival. Resveratrol produces changes associated with longer lifespan, including increased insulin sensitivity, reduced insulin-like growth factor-1 (IGF-I) levels, increased AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor- gamma coactivator 1 alpha (PGC-1 alpha ) activity, increased mitochondrial number, and improved motor function. Parametric analysis of gene set enrichment revealed that resveratrol opposed the effects of the high-calorie diet in 144 out of 153 significantly altered pathways. These data show that improving general health in mammals using small molecules is an attainable goal, and point to new approaches for treating obesity-related disorders and diseases of ageing.