identified two new genes forAlzheimer's disease

作者:TCM  于 2010-5-12 09:24 发表于 最热闹的华人社交网络--贝壳村

通用分类:网络文摘|已有4评论

US and European researchers have identified two new genes that may play a role in the development of Alzheimer's disease and could help unravel new treatments, a study published Tuesday said.

Researchers have now uncovered nine genes they believe are involved in the development of Alzheimer's Disease (AD), according to a study published in the May 12 issue of the Journal of the American Medical Association.

"Identifying each of these new genes... points to new biological pathways involved in the development of AD," said senior author Sudha Seshadri, an associate professor of neurology at the Boston University School of Medicine.

"Although such benefits are likely a decade away, studying these pathways should lead to new ways to postpone, prevent and perhaps treat the disease."

The researchers were able to assemble the largest sample to date for their study by combining their data with previously-published material, creating a sample of 35,000 people, over 8,000 of whom developed Alzheimer's.

"This highly collaborative international effort enabled researchers to build the large sample size needed to identify elusive gene variants that may play a role in this devastating neurological disease," said Marilyn Miller of the National Institute on Aging.

"Such collaborations are key to a fuller understanding of the many genetic factors that may contribute to overall risk for late onset Alzheimer's and how these genes affect the development of the disease."

The National Institute on Aging is part of the US National Institutes of Health and helped fund the collection of data for the study, as well as its analysis.

It is estimated that one in five people aged 65 or older will develop Alzheimer's over the remainder of their lifetime.

Certain genetic variations are believed to play a key role in the development of Alzheimer's, which is more likely to affect people who have a family history of the disease.


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发表评论 评论 (4 个评论)

0 回复 marnifan 2010-5-12 09:33
too general~ where is this article from?
0 回复 TCM 2010-5-12 09:41
marnifan: too general~ where is this article from?
Researchers from Boston University School of Medicine, in collaboration with scientists from the Rotterdam Study led by professor Monique Breteler; the Cardiovascular Health Study led by professor Oscar Lopez; the AGES-Reyjavik study led by Prof. Lenore Launer; the Mayo AD study led by professor Steve Younkin; the European AD Consortium lead by professor Philippe Amouyel; the Genetic and Environmental Risk in Alzheimer's Disease consortium led by professor Julie Williams and the Fundació ACE study in Barcelona led by professor Merce Boada, have identified two new genes that may be risk factors for the development of late-onset Alzheimer's disease (AD).Using an intensive, genome-wide association analysis study (GWAS), the researchers identified two new genes at specific locations in the DNA called loci that reached the required genome-wide statistical significance threshold for the first time, thus identifying them as very likely associated with AD. They were found on chromosomes 2 and 19, the first being close to a gene called BIN1 (Bridging Intergrator 1) on chromosome 2 and the second being close to several genes including EXOC3L2, BLOC1S3 and MARK4 on chromosome 19. These findings were replicated in an independent population.
0 回复 marnifan 2010-5-12 09:47
TCM: Researchers from Boston University School of Medicine, in collaboration with scientists from the Rotterdam Study led by professor Monique Breteler; t
thank you~
0 回复 cartoonyang 2010-5-12 14:12
GOOD NEWS!

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